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Article

Notch2 controls hepatocyte-derived cholangiocarcinoma formation in mice

14 Mar 2018

Abstract excerpt

Liver cancer comprises a group of malignant tumors, among which hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) are the most common. ICC is especially pernicious and associated with poor clinical outcome. Studies have shown that a subset of human ICCs may originate from mature hepatocytes. However, the mechanisms driving the trans-differentiation of hepatocytes into malignant...

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PMID: 29545603
DOI: 10.1038/s41388-018-0188-1

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