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Article

Intrahepatic cholangiocarcinoma can arise from Notch-mediated conversion of hepatocytes

1 Oct 2012

Abstract excerpt

Intrahepatic cholangiocarcinoma (ICC) is the second most common primary malignancy in the liver. ICC has been classified as a malignant tumor arising from cholangiocytes; however, the co-occurrence of ICC and viral hepatitis suggests that ICC originates in hepatocytes. In order to determine the cellular origin of ICC, we used a mouse model of ICC in which hepatocytes and cholangiocytes were labeled with...

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PMID: 23023701
DOI: 10.1172/jci63065

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