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Article

Endogenous interferon gamma protects against cholestatic liver injury in mice.

Hepatology (Baltimore, Md.) - 1 Dec 2002

Sewnath Miguel E, Van Der Poll Tom, Van Noorden Cornelis J F, Ten Kate Fiebo J W, Gouma Dirk J

Abstract excerpt

Cholestatic patients suffer from high perioperative morbidity and mortality, but the pathophysiology is still unknown. Interferon gamma (IFN-gamma) may play a role during cholestasis. Therefore, bile duct ligation (BDL) was induced in IFN-gamma alpha-chain receptor-deficient (IFN-gammaR(1)-/-) and wild-type (IFN-gammaR(1)+/+) mice. BDL elicited increased IFN-gamma messenger RNA and protein levels in the liver....

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Source

Identifiers

PMID: 12447873
DOI: 10.1053/jhep.2002.37196

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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