Genetic polymorphisms of p21 are associated with risk of squamous cell carcinoma of the head and neck.

doi:10.1093/carcin/bgi105

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Article

Genetic polymorphisms of p21 are associated with risk of squamous cell carcinoma of the head and neck.

Carcinogenesis - 1 Sept 2005

Li Guojun, Liu Zhensheng, Sturgis Erich M, Shi Qiuling, Chamberlain Robert M, Spitz Margaret R, Wei Qingyi

Abstract excerpt

The p21 (Waf1/Cip1/CDKN1A) protein regulates the transition from the G1 to the S phase and has an important role in modulating cell-cycle control, apoptosis and cell growth. Two polymorphisms of the p21 gene at codon 31 (p21 C98A, dbSNP rs1801270) and at the 3' untranslated region (p21 T70C, dbSNP rs1059234) may have an effect on the protein function and may thus play a role in the development of cancer. We...

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PMID: 15878916
DOI: 10.1093/carcin/bgi105

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