P21(waf1/cip1) gene polymorphisms and possible interaction with cigarette smoking in esophageal squamous cell carcinoma in northeastern Iran: a preliminary study.

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P21(waf1/cip1) gene polymorphisms and possible interaction with cigarette smoking in esophageal squamous cell carcinoma in northeastern Iran: a preliminary study.

Archives of Iranian medicine - 1 May 2010

Taghavi Noushin, Biramijamal Firouzeh, Abbaszadegan Mohammad Reza, Khademi Hooman, Sotoudeh Masoud, Khoshbakht Shahrouz

Abstract excerpt

BACKGROUND: The incidence of esophageal squamous cell carcinoma (ESCC) is very high in northeastern Iran. However, the genetic predisposing factors to ESCC in this region have not been clearly defined. The P21(waf1/cip1) gene is involved in the arrest of cellular growth, as induced by the p53 tumor suppressor gene. Two polymorphisms of p21 gene in codon 31 (p21 C98A, dbSNP rs1801270) and the 3'UTR (p21 C70T,...

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PMID: 20433229

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