Genetic variants of p21 and p27 and pancreatic cancer risk in non-Hispanic Whites: a case-control study.

doi:10.1097/MPA.0b013e3181bd51c8

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Article

Genetic variants of p21 and p27 and pancreatic cancer risk in non-Hispanic Whites: a case-control study.

Pancreas - 1 Jan 2010

Chen Jinyun, Amos Christopher I, Merriman Kelly W, Wei Qingyi, Sen Subrata, Killary Ann M, Frazier Marsha L

Abstract excerpt

OBJECTIVES: p21 (WAF1/Cip1/CDKN1A) and p27 (Kip1/CDKN1B) are members of the Cip/Kip family of cyclin-dependent kinase inhibitors, which can induce cell cycle arrest and serve as tumor suppressors. We hypothesized that genetic variants in p21 and p27 may modify individual susceptibility to pancreatic cancer. METHODS: To test this hypothesis, we evaluated the associations of the Ser31Arg polymorphism in p21 and the...

Topics

Aged
Alleles
Case-Control Studies
Chi-Square Distribution
Cyclin-Dependent Kinase Inhibitor p21
Cyclin-Dependent Kinase Inhibitor p27
Female
Gene Frequency
Genetic Predisposition to Disease
Genetic Variation
Genotype
Humans
Male

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Odds Ratio

Pancreatic Neoplasms

Polymorphism, Single Nucleotide

Risk Factors

Source

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Identifiers

PMID: 19910837
DOI: 10.1097/MPA.0b013e3181bd51c8
PMCID: PMC2796289

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