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Association of p53 and p21(CDKN1A/WAF1/CIP1) polymorphisms with oral cancer in Taiwan patients.

Anticancer research - 1 Jan 2000

Bau Da-Tian, Tsai Ming-Hsui, Lo Yen-Li, Hsu Chin-Moo, Tsai Yuhsin, Lee Cheng-Chun, Tsai Fuu-Jen

Abstract excerpt

BACKGROUND: The tumor suppressor gene p53 and its downstream effector p21(CDKN1A/WAF1/CIP1) are thought to play major roles in the development of human malignancy. Polymorphic variants of p53, at codon 72, and CDKN1A, at codon 31, have been associated with cancer susceptibility, but few studies have investigated their effect on oral cancer risk. MATERIALS AND METHODS: In this hospital-based case-control study,...

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PMID: 17595776

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