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Article

Genetic variants of p27 and p21 as predictors for risk of second primary malignancy in patients with index squamous cell carcinoma of head and neck.

Molecular cancer - 26 Mar 2012

Wang Zhongqiu, Sturgis Erich M, Zhang Fenghua, Lei Dapeng, Liu Zhensheng, Xu Li, Song Xicheng, Wei Qingyi, Li Guojun

Abstract excerpt

BACKGROUND: Cell cycle deregulation is common in human cancer, and alterations of p27 and p21, two critical cell cycle regulators, have been implicated in the development of many human malignancies. Therefore, we hypothesize that p27 T109G polymorphism individually or in combination with p21 (C98A and C70T) polymorphisms modifies risk of second primary malignancy (SPM) in patients with index squamous cell...

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Share to Carcinoma, Squamous Cell
Share to Cyclin-Dependent Kinase Inhibitor p21

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genetic Predisposition to Disease

Share to Head and Neck Neoplasms

Share to Neoplasms, Second Primary

Share to Polymorphism, Genetic

Share to Squamous Cell Carcinoma of Head and Neck

Source

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Identifiers

PMID: 22449259
DOI: 10.1186/1476-4598-11-17
PMCID: PMC3331801

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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