Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association between human cancer and two polymorphisms occurring together in the p21Waf1/Cip1 cyclin-dependent kinase inhibitor gene

15 Jun 1997

Abstract excerpt

BACKGROUND: The cyclin-dependent kinase inhibitor gene p21Waf1/Cip1 plays a role in signaling cellular growth arrest. In response to DNA damage, p21 is induced by the p53 gene, thereby playing a direct role in mediating p53-induced G1 arrest. Alterations in this gene may adversely affect regulation of cellular proliferation and increase susceptibility for cancer. Two polymorphisms have previously been...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Research and Disease Studies
Share to Cancer-related Molecular Pathways
Share to TGF-β signaling in diseases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9191533
DOI: 10.1002/(sici)1097-0142(19970615)79:12<2424::aid-cncr19>3.0.co;2-t

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association between human cancer and two polymorphisms occurring together in the p21Waf1/Cip1 cyclin-dependent kinase inhibitor genePMID 9191533Read ↗

Genetic polymorphisms of p21 are associated with risk of squamous cell carcinoma of the head and neck.Semantic proximity Read ↗

Expression and sequence analysis of the p21(WAF1/CIP1) gene in renal cancers.Semantic proximity Read ↗

Association between p21 Ser31Arg polymorphism and cancer risk: a meta-analysis.Semantic proximity Read ↗

p21WAF1 and tumourigenesisSemantic proximity Read ↗

Genetic variants of p21 and p27 and pancreatic cancer risk in non-Hispanic Whites: a case-control study.Semantic proximity Read ↗

P21 codon 31 polymorphism associated with cancer among white people: evidence from a meta-analysis involving 78,074 subjects.Semantic proximity Read ↗

Association between polymorphism in p21(Waf1/Cip1) cyclin-dependent kinase inhibitor gene and human oral cancer.Semantic proximity Read ↗

p21WAF1 mutations and human malignancies.Semantic proximity Read ↗

Novel polymorphism in p21waf1/cip1 cyclin dependent kinase inhibitor gene: association with human esophageal cancerSemantic proximity Read ↗

p21 and p27: roles in carcinogenesis and drug resistanceSemantic proximity Read ↗

CDKN1A/p21 in Breast Cancer: Part of the Problem, or Part of the Solution?Semantic proximity Read ↗

p21 contains independent binding sites for cyclin and cdk2: both sites are required to inhibit cdk2 kinase activity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.