Article
Target-selected mutant screen by TILLING in Drosophila.
Genome research - 1 May 2005
Winkler Sylke, Schwabedissen Anja, Backasch Dana, Bökel Christian, Seidel Claudia, Bönisch Stefanie, Fürthauer Maximilian, Kuhrs Antje, Cobreros Laura, Brand Michael, González-Gaitán Marcos
Abstract excerpt
The availability of the full Drosophila genomic DNA sequence prompts the development of a method to efficiently obtain mutations in genes of interest identified by their sequence homologies or biochemically. To date, molecularly characterized mutations have been generated in around 6000 of the approximately 15,000 annotated fly genes, of which around one-third are essential for viability. To obtain mutations in...
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