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Article

Targeted screening for induced mutations.

Nature biotechnology - 1 Apr 2000

McCallum C M, Comai L, Greene E A, Henikoff S

Abstract excerpt

With the accumulation of large-scale sequence data, emphasis in genomics has shifted from determining gene structure to testing gene function, and this relies on reverse genetic methodology. Here we explore the feasibility of screening for chemically induced mutations in target sequences in Arabidopsis thaliana. Our TILLING (Targeting Induced Local Lesions IN Genomes) method combines the efficiency of ethyl...

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PMID: 10748531
DOI: 10.1038/74542

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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