Article
EMS screens : from mutagenesis to screening and mapping.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2008
Bökel Christian
Abstract excerpt
The success of Drosophila as a genetic model organism is based on the efficient generation, recovery, and identification of new mutations. Various agents have been used to induce de novo DNA lesions. However, the use of mutagenic alkylating agents, especially ethyl methanesulfonate (EMS), has become a standard approach for mutagenesis that has been succesfully used in the classic forward genetic screens that have...
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