Mutant generation in vertebrate model organisms by TILLING.

doi:10.1007/978-1-61779-210-6_19

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Article

Mutant generation in vertebrate model organisms by TILLING.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2011

Winkler Sylke, Gscheidel Nicola, Brand Michael

Abstract excerpt

TILLING (Targeting Induced Local Lesions IN Genomes) is a popular reverse genetic approach that has been successfully applied in several genetic model organisms such as zebrafish, rat, Drosophila, Arabidopsis, or medaka. In contrast to classical targeted knockout technologies that work in mice by directly targeting a gene of interest, TILLING follows an indirect strategy. The first step of the TILLING pipeline is...

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PMID: 21805277
DOI: 10.1007/978-1-61779-210-6_19

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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