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From the Cover: Directed, efficient, and versatile modifications of the Drosophila genome by genomic engineering.

Proceedings of the National Academy of Sciences of the United States of America - 19 May 2009

Huang Juan, Zhou Wenke, Dong Wei, Watson Annie M, Hong Yang

Abstract excerpt

With the completion of genome sequences of major model organisms, increasingly sophisticated genetic tools are necessary for investigating the complex and coordinated functions of genes. Here we describe a genetic manipulation system termed "genomic engineering" in Drosophila. Genomic engineering is a 2-step process that combines the ends-out (replacement) gene targeting with phage integrase phiC31-mediated DNA...

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PMID: 19429710
DOI: 10.1073/pnas.0900641106
PMCID: PMC2688891

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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