Article
Large-scale identification of chemically induced mutations in Drosophila melanogaster.
Genome research - 1 Oct 2014
Haelterman Nele A, Jiang Lichun, Li Yumei, Bayat Vafa, Sandoval Hector, Ugur Berrak, Tan Kai Li, Zhang Ke, Bei Danqing, Xiong Bo, Charng Wu-Lin, Busby Theodore, Jawaid Adeel, David Gabriela, Jaiswal Manish, Venken Koen J T, Yamamoto Shinya, Chen Rui, Bellen Hugo J
Abstract excerpt
Forward genetic screens using chemical mutagens have been successful in defining the function of thousands of genes in eukaryotic model organisms. The main drawback of this strategy is the time-consuming identification of the molecular lesions causative of the phenotypes of interest. With whole-genome sequencing (WGS), it is now possible to sequence hundreds of strains, but determining which mutations are...
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