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Article

Retention of induced mutations in a Drosophila reverse-genetic resource.

Genetics - 1 Sept 2008

Cooper Jennifer L, Greene Elizabeth A, Till Bradley J, Codomo Christine A, Wakimoto Barbara T, Henikoff Steven

Abstract excerpt

Targeting induced local lesions in genomes (TILLING) is a reverse-genetic method for identifying point mutations in chemically mutagenized populations. For functional genomics, it is ideal to have a stable collection of heavily mutagenized lines that can be screened over an extended period of time. However, long-term storage is impractical for Drosophila, so mutant strains must be maintained by continual...

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Identifiers

PMID: 18780737
DOI: 10.1534/genetics.108.092437
PMCID: PMC2535715

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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