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Article

Intricate targeting of immunoglobulin somatic hypermutation maximizes the efficiency of affinity maturation.

The Journal of experimental medicine - 2 May 2005

Zheng Nai-Ying, Wilson Kenneth, Jared Matthew, Wilson Patrick C

Abstract excerpt

It is believed that immunoglobulin-variable region gene (IgV) somatic hypermutation (SHM) is initiated by activation-induced cytidine deaminase (AID) upon deamination of cytidine to deoxyuracil. Patch-excision repair of these lesions involving error prone DNA polymerases such as poleta causes mutations at all base positions. If not repaired, the deaminated nucleotides on the coding and noncoding strands result in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 15867095
DOI: 10.1084/jem.20042483
PMCID: PMC2213188

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Intricate targeting of immunoglobulin somatic hypermutation maximizes the efficiency of affinity maturation.PMID 15867095Read ↗

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DNA flexibility can shape the preferential hypermutation of antibody genes.Semantic proximity Read ↗

Controlling somatic hypermutation in immunoglobulin variable and switch regions.Semantic proximity Read ↗

Somatic mutation patterns at Ig and Non-Ig Loci.Semantic proximity Read ↗

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