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Article

Intricate targeting of immunoglobulin somatic hypermutation maximizes the efficiency of affinity maturation.

The Journal of experimental medicine - 2 May 2005

Zheng Nai-Ying, Wilson Kenneth, Jared Matthew, Wilson Patrick C

Abstract excerpt

It is believed that immunoglobulin-variable region gene (IgV) somatic hypermutation (SHM) is initiated by activation-induced cytidine deaminase (AID) upon deamination of cytidine to deoxyuracil. Patch-excision repair of these lesions involving error prone DNA polymerases such as poleta causes mut...

Topics

B-Lymphocytes
Base Sequence
Codon
Cytidine Deaminase
Cytosine Deaminase
DNA Repair
DNA-Directed DNA Polymerase
Evolution, Molecular
Flow Cytometry
Humans
Immunoglobulin Variable Region
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Sequence Analysis, DNA

Somatic Hypermutation, Immunoglobulin

AICDA (Activation-Induced Cytidine Deaminase)

Source

Open in PubMed Open full text

Identifiers

PMID: 15867095
DOI: 10.1084/jem.20042483
PMCID: PMC2213188

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-15867095-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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