Article
Gene-gene interactions between CYP2B6 and CYP2A6 in nicotine metabolism.
Pharmacogenetics and genomics - 1 Dec 2007
Ring Huijun Z, Valdes Ana M, Nishita Denise M, Prasad Suman, Jacob Peyton, Tyndale Rachel F, Swan Gary E, Benowitz Neal L
Abstract excerpt
OBJECTIVES: CYP2A6 is the major enzyme involved in nicotine metabolism, yet large interindividual variations in the rate of nicotine metabolism exist within groups of individuals having the same CYP2A6 genotype. We investigated the influence of genetic variation in another potential nicotine-meta...
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