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Article

CYP2A6 genotype and the metabolism and disposition kinetics of nicotine.

Clinical pharmacology and therapeutics - 1 Nov 2006

Benowitz Neal L, Swan Gary E, Jacob Peyton, Lessov-Schlaggar Christina N, Tyndale Rachel F

Abstract excerpt

BACKGROUND AND OBJECTIVE: The liver enzyme cytochrome P450 (CYP) 2A6 is primarily responsible for the metabolism of nicotine. Variants in the CYP2A6 gene have been associated with altered nicotine metabolism and with effects on smoking behavior. Our objective was to determine the relationship between variant CYP2A6 genotypes and the disposition and metabolism of nicotine administered intravenously. METHODS:...

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Identifiers

PMID: 17112802
DOI: 10.1016/j.clpt.2006.08.011

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