Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Determinants of the rate of nicotine metabolism and effects on smoking behavior.

Clinical pharmacology and therapeutics - 1 Oct 2006

Johnstone Elaine, Benowitz Neal, Cargill Anna, Jacob Robyn, Hinks Lesley, Day Ian, Murphy Mike, Walton Robert

Abstract excerpt

BACKGROUND: Studies on cytochrome P450 (CYP) 2A6 suggest that genotype affects the rate of nicotine metabolism and, consequently, cigarette consumption. However, known alleles of CYP2A6 associated with fast or slow metabolism are relatively uncommon, and there remains considerable variation in metabolic activity among those with presumed wild-type CYP2A6 alleles, suggesting that other genetic or environmental...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aryl Hydrocarbon Hydroxylases
Share to Cytochrome P-450 CYP2A6

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2B6

Share to Mixed Function Oxygenases

Share to Nicotine

Share to Nicotinic Agonists

Share to Oxidoreductases, N-Demethylating

Share to Smoking Cessation

Source

Identifiers

PMID: 17015050
DOI: 10.1016/j.clpt.2006.06.011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Determinants of the rate of nicotine metabolism and effects on smoking behavior.PMID 17015050Read ↗

Genetic variability in CYP2A6 and the pharmacokinetics of nicotine.Semantic proximity Read ↗

CYP2A6 genotype and the metabolism and disposition kinetics of nicotine.Semantic proximity Read ↗

Nicotine dependence pharmacogenetics: role of genetic variation in nicotine-metabolizing enzymes.Semantic proximity Read ↗

The contribution of common CYP2A6 alleles to variation in nicotine metabolism among European-Americans.Semantic proximity Read ↗

Disposition kinetics and metabolism of nicotine and cotinine in African American smokers: impact of CYP2A6 genetic variation and enzymatic activity.Semantic proximity Read ↗

Gene-gene interactions between CYP2B6 and CYP2A6 in nicotine metabolism.Semantic proximity Read ↗

Nicotine metabolism: the impact of CYP2A6 on estimates of additive genetic influence.Semantic proximity Read ↗

[Role of cytochrome P450 2A6 polymorphism in nicotine metabolism and tobacco-dependent behaviour].Semantic proximity Read ↗

Smoking behavior and related cancers: the role of CYP2A6 polymorphisms.Semantic proximity Read ↗

Nicotine Metabolism Predicted by CYP2A6 Genotypes in Relation to Smoking Cessation: A Systematic Review.Semantic proximity Read ↗

Association of nicotine metabolite ratio and CYP2A6 genotype with smoking cessation treatment in African-American light smokers.Semantic proximity Read ↗

CYP2A6 genotype, phenotype, and the use of nicotine metabolites as biomarkers during ad libitum smoking.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.