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Article

The normal patched allele is expressed in medulloblastomas from mice with heterozygous germ-line mutation of patched.

Cancer research - 15 Apr 2000

Wetmore C, Eberhart D E, Curran T

Abstract excerpt

Defects in a developmental signaling pathway involving mammalian homologues of the Drosophila segment polarity gene, patched (ptc) and its ligand, sonic hedgehog (shh), contribute to tumor formation in several tissues. Recently, a subset of medulloblastoma, the most common malignant brain tumor in children, was found to contain somatic mutations in the human ptc gene. In addition, basal cell nevus syndrome...

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Identifiers

PMID: 10786690

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The normal patched allele is expressed in medulloblastomas from mice with heterozygous germ-line mutation of patched.PMID 10786690Read ↗

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