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Article

Tis21 knock-out enhances the frequency of medulloblastoma in Patched1 heterozygous mice by inhibiting the Cxcl3-dependent migration of cerebellar neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 31 Oct 2012

Farioli-Vecchioli Stefano, Cinà Irene, Ceccarelli Manuela, Micheli Laura, Leonardi Luca, Ciotti Maria Teresa, De Bardi Marco, Di Rocco Concezio, Pallini Roberto, Cavallaro Sebastiano, Tirone Felice

Abstract excerpt

A failure in the control of proliferation of cerebellar granule neuron precursor cells (GCPs), located in the external granular layer (EGL) of the cerebellum, gives rise to medulloblastoma. To investigate the process of neoplastic transformation of GCPs, we generated a new medulloblastoma model by crossing Patched1 heterozygous mice, which develop medulloblastomas with low frequency, with mice lacking the Tis21...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23115191
DOI: 10.1523/JNEUROSCI.0412-12.2012
PMCID: PMC6621585

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