Article
Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells.
Cancer cell - 12 Aug 2008
Yang Zeng-Jie, Ellis Tammy, Markant Shirley L, Read Tracy-Ann, Kessler Jessica D, Bourboulas Melissa, Schüller Ulrich, Machold Robert, Fishell Gord, Rowitch David H, Wainwright Brandon J, Wechsler-Reya Robert J
Abstract excerpt
Medulloblastoma is the most common malignant brain tumor in children, but the cells from which it arises remain unclear. Here we examine the origin of medulloblastoma resulting from mutations in the Sonic hedgehog (Shh) pathway. We show that activation of Shh signaling in neuronal progenitors causes medulloblastoma by 3 months of age. Shh pathway activation in stem cells promotes stem cell proliferation but only...
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