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Article

Two tumor suppressors, p27Kip1 and patched-1, collaborate to prevent medulloblastoma.

Molecular cancer research : MCR - 1 Jan 2009

Ayrault Olivier, Zindy Frederique, Rehg Jerold, Sherr Charles J, Roussel Martine F

Abstract excerpt

Two cyclin-dependent kinase inhibitors, p18(Ink4c) and p27(Kip1), are required for proper cerebellar development. Loss of either of these proteins conferred a proliferative advantage to granule neuron progenitors, although inactivation of Kip1 exerted a greater effect. Mice heterozygous for Patched-1 (Ptc1+/-) that are either heterozygous or nullizygous for Kip1 developed medulloblastoma rapidly and with high...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19147535
DOI: 10.1158/1541-7786.MCR-08-0369
PMCID: PMC2637533

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Two tumor suppressors, p27Kip1 and patched-1, collaborate to prevent medulloblastoma.PMID 19147535Read ↗

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