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Article

Thickened area of external granular layer and Ki-67 positive focus are early events of medulloblastoma in Ptch1⁺/⁻ mice.

Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie - 1 Sept 2013

Matsuo Saori, Takahashi Miwa, Inoue Kaoru, Tamura Kei, Irie Kaoru, Kodama Yukio, Nishikawa Akiyoshi, Yoshida Midori

Abstract excerpt

Patched1 (Ptch1) encodes a receptor for Sonic hedgehog (Shh) and is major gene related to human medulloblastoma (MB) in the Shh subgroup. MB is thought to arise from residual granule cell precursors (GCPs) located in the external granular layer (EGL) of the developing cerebellum. As the detailed preneoplastic changes of MB remain obscure, we immunohistochemically clarified the derived cell, early events of MBs,...

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Identifiers

PMID: 23369240
DOI: 10.1016/j.etp.2012.12.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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