Article
Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation.
Development (Cambridge, England) - 1 May 2005
Stennard Fiona A, Costa Mauro W, Lai Donna, Biben Christine, Furtado Milena B, Solloway Mark J, McCulley David J, Leimena Christiana, Preis Jost I, Dunwoodie Sally L, Elliott David E, Prall Owen W J, Black Brian L, Fatkin Diane, Harvey Richard P
Abstract excerpt
The genetic hierarchies guiding lineage specification and morphogenesis of the mammalian embryonic heart are poorly understood. We now show by gene targeting that murine T-box transcription factor Tbx20 plays a central role in these pathways, and has important activities in both cardiac development and adult function. Loss of Tbx20 results in death of embryos at mid-gestation with grossly abnormal heart...
Topics
- Animals
- Blotting, Northern
- Cell Differentiation
- Echocardiography
- Gene Expression Regulation, Developmental
- Gene Targeting
- Heart
- Histocytochemistry
- In Situ Hybridization