Tbx2 and Tbx3 Regulate the Dynamics of Cell Proliferation during Heart Remodeling

doi:10.1371/journal.pone.0000398

Article

Tbx2 and Tbx3 Regulate the Dynamics of Cell Proliferation during Heart Remodeling

24 Apr 2007

Abstract excerpt

BACKGROUND: The heart forms from a linear tube that is subject to complex remodeling during embryonic development. Hallmarks of this remodeling are the looping of the heart tube and the regionalization into chamber and non-chamber myocardium. Cardiomyocytes in the future chamber myocardium acquire different cellular and physiological characteristics through activation of a chamber-specific genetic program, which...

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