Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lack of Genetic Interaction between Tbx18 and Tbx2/Tbx20 in Mouse Epicardial Development.

PloS one - 1 Jan 2016

Greulich Franziska, Rudat Carsten, Farin Henner F, Christoffels Vincent M, Kispert Andreas

Abstract excerpt

The epicardium, the outermost layer of the heart, is an essential source of cells and signals for the formation of the cardiac fibrous skeleton and the coronary vasculature, and for the maturation of the myocardium during embryonic development. The molecular factors that control epicardial mobilization and differentiation, and direct the epicardial-myocardial cross-talk are, however, insufficiently understood....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Epistasis, Genetic
Share to Epithelial-Mesenchymal Transition

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Dosage

Share to Gene Expression Regulation, Developmental

Share to Pericardium

Share to T-Box Domain Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 27253890
DOI: 10.1371/journal.pone.0156787
PMCID: PMC4890940

Genes

TBX18

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lack of Genetic Interaction between Tbx18 and Tbx2/Tbx20 in Mouse Epicardial Development.PMID 27253890Read ↗

Tbx18 function in epicardial development.Semantic proximity Read ↗

Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation.Semantic proximity Read ↗

Tbx20 is essential for cardiac chamber differentiation and repression of Tbx2.Semantic proximity Read ↗

Lack of genetic interaction between Tbx20 and Tbx3 in early mouse heart development.Semantic proximity Read ↗

Tbx20 acts upstream of Wnt signaling to regulate endocardial cushion formation and valve remodeling during mouse cardiogenesisSemantic proximity Read ↗

Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart.Semantic proximity Read ↗

Tbx20 Is Required in Mid-Gestation Cardiomyocytes and Plays a Central Role in Atrial Development.Semantic proximity Read ↗

The Role of Tbx20 in Cardiovascular Development and FunctionSemantic proximity Read ↗

Tbx2 and Tbx3 induce atrioventricular myocardial development and endocardial cushion formationSemantic proximity Read ↗

T‐box transcription factor Tbx2 represses differentiation and formation of the cardiac chambersSemantic proximity Read ↗

Tbx20 interacts with smads to confine tbx2 expression to the atrioventricular canal.Semantic proximity Read ↗

Disruption of myocardial Gata4 and Tbx5 results in defects in cardiomyocyte proliferation and atrioventricular septationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.