Article
Tbx20 interacts with smads to confine tbx2 expression to the atrioventricular canal.
Circulation research - 28 Aug 2009
Singh Reena, Horsthuis Thomas, Farin Henner F, Grieskamp Thomas, Norden Julia, Petry Marianne, Wakker Vincent, Moorman Antoon F M, Christoffels Vincent M, Kispert Andreas
Abstract excerpt
RATIONALE: T-box transcription factors play critical roles in the coordinated formation of the working chambers and the atrioventricular canal (AVC). Tbx2 patterns embryonic myocardial cells to form the AVC and suppresses their differentiation into chamber myocardium. Tbx20-deficient embryos, which fail to form chambers, ectopically express Tbx2 throughout the entire heart tube, providing a potential mechanism...
Topics
- Animals
- Base Sequence
- Binding Sites
- Bone Morphogenetic Proteins
- Cell Differentiation
- Endocardial Cushions
- Gene Expression Regulation, Developmental
- Gestational Age
- HeLa Cells
- Heart Atria
- Heart Ventricles
- Humans
- Mice