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Article

Tbx20 interacts with smads to confine tbx2 expression to the atrioventricular canal.

Circulation research - 28 Aug 2009

Singh Reena, Horsthuis Thomas, Farin Henner F, Grieskamp Thomas, Norden Julia, Petry Marianne, Wakker Vincent, Moorman Antoon F M, Christoffels Vincent M, Kispert Andreas

Abstract excerpt

RATIONALE: T-box transcription factors play critical roles in the coordinated formation of the working chambers and the atrioventricular canal (AVC). Tbx2 patterns embryonic myocardial cells to form the AVC and suppresses their differentiation into chamber myocardium. Tbx20-deficient embryos, which fail to form chambers, ectopically express Tbx2 throughout the entire heart tube, providing a potential mechanism...

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Source

Identifiers

PMID: 19661464
DOI: 10.1161/CIRCRESAHA.109.196063

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Tbx20 interacts with smads to confine tbx2 expression to the atrioventricular canal.PMID 19661464Read ↗

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T‐box transcription factor Tbx2 represses differentiation and formation of the cardiac chambersSemantic proximity Read ↗

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Tbx20 Is Required in Mid-Gestation Cardiomyocytes and Plays a Central Role in Atrial Development.Semantic proximity Read ↗

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Tbx2 and Tbx3 induce atrioventricular myocardial development and endocardial cushion formationSemantic proximity Read ↗

Tbx20 acts upstream of Wnt signaling to regulate endocardial cushion formation and valve remodeling during mouse cardiogenesisSemantic proximity Read ↗

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Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart.Semantic proximity Read ↗

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