Article
Tbx20 is essential for cardiac chamber differentiation and repression of Tbx2.
Development (Cambridge, England) - 1 Jun 2005
Singh Manvendra K, Christoffels Vincent M, Dias José M, Trowe Mark-Oliver, Petry Marianne, Schuster-Gossler Karin, Bürger Antje, Ericson Johan, Kispert Andreas
Abstract excerpt
Tbx20, a member of the T-box family of transcriptional regulators, shows evolutionary conserved expression in the developing heart. In the mouse, Tbx20 is expressed in the cardiac crescent, then in the endocardium and myocardium of the linear and looped heart tube before it is restricted to the atrioventricular canal and outflow tract in the multi-chambered heart. Here, we show that Tbx20 is required for...
Topics
- Animals
- Apoptosis
- Body Patterning
- Cell Differentiation
- Cell Proliferation
- Gene Expression Regulation, Developmental
- Heart
- Mice
- Mice, Knockout
- Mutation
- Myocardium