Article
Mutations in cardiac T-box factor gene TBX20 are associated with diverse cardiac pathologies, including defects of septation and valvulogenesis and cardiomyopathy.
American journal of human genetics - 1 Aug 2007
Kirk Edwin P, Sunde Margaret, Costa Mauro W, Rankin Scott A, Wolstein Orit, Castro M Leticia, Butler Tanya L, Hyun Changbaig, Guo Guanglan, Otway Robyn, Mackay Joel P, Waddell Leigh B, Cole Andrew D, Hayward Christopher, Keogh Anne, Macdonald Peter, Griffiths Lyn, Fatkin Diane, Sholler Gary F, Zorn Aaron M, Feneley Michael P, Winlaw David S, Harvey Richard P
Abstract excerpt
The T-box family transcription factor gene TBX20 acts in a conserved regulatory network, guiding heart formation and patterning in diverse species. Mouse Tbx20 is expressed in cardiac progenitor cells, differentiating cardiomyocytes, and developing valvular tissue, and its deletion or RNA interfe...
Topics
- Adolescent
- Adult
- Aged
- Cardiomyopathies
- Cardiomyopathy, Dilated
- Child
- Child, Preschool
- Codon, Nonsense
- Female
- Heart