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Article

HIV-1 subtype variability in Vif derived from molecular clones affects APOBEC3G-mediated host restriction.

Intervirology - 1 Jan 2013

Lisovsky Irene, Schader Susan M, Sloan Richard D, Oliveira Maureen, Coutsinos Dimitrios, Bernard Nicole F, Wainberg Mark A

Abstract excerpt

BACKGROUND: The host protein APOBEC3G (A3G) can limit HIV-1 replication. Its protective effect is overcome by the HIV-1 'viral infectivity factor' (Vif), which targets A3G for proteosomal degradation. Although Vif is considered to be essential for HIV-1 replication, the effect of Vif variability among commonly used HIV-1 molecular clones of different genetic backgrounds on viral infectiousness and pathogenesis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to vif Gene Products, Human Immunodeficiency Virus

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Source

Identifiers

PMID: 23689841
DOI: 10.1159/000348513

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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