Article
Function of mammalian LKB1 and Ca2+/calmodulin-dependent protein kinase kinase alpha as Snf1-activating kinases in yeast.
The Journal of biological chemistry - 10 Jun 2005
Hong Seung-Pyo, Momcilovic Milica, Carlson Marian
Abstract excerpt
The Snf1/AMP-activated protein kinase (AMPK) family is important for metabolic regulation in response to stress. In the yeast Saccharomyces cerevisiae, the Snf1 kinase cascade comprises three Snf1-activating kinases, Pak1, Tos3, and Elm1. The only established mammalian AMPK kinase is LKB1. We show that LKB1 functions heterologously in yeast. In pak1Delta tos3Delta elm1Delta cells, LKB1 activated Snf1 catalytic...
Topics
- AMP-Activated Protein Kinases
- Animals
- Calcium-Calmodulin-Dependent Protein Kinase Kinase
- Carbon
- Catalysis
- Cell Nucleus
- Cell Proliferation
- DNA, Complementary
- Dose-Response Relationship, Drug
- Glucose