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Article

ADP regulates SNF1, the Saccharomyces cerevisiae homolog of AMP-activated protein kinase.

Cell metabolism - 2 Nov 2011

Mayer Faith V, Heath Richard, Underwood Elizabeth, Sanders Matthew J, Carmena David, McCartney Rhonda R, Leiper Fiona C, Xiao Bing, Jing Chun, Walker Philip A, Haire Lesley F, Ogrodowicz Roksana, Martin Stephen R, Schmidt Martin C, Gamblin Steven J, Carling David

Abstract excerpt

The SNF1 protein kinase complex plays an essential role in regulating gene expression in response to the level of extracellular glucose in budding yeast. SNF1 shares structural and functional similarities with mammalian AMP-activated protein kinase. Both kinases are activated by phosphorylation on a threonine residue within the activation loop segment of the catalytic subunit. Here we show that ADP is the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 22019086
DOI: 10.1016/j.cmet.2011.09.009
PMCID: PMC3241989

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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