Article
Pak1 protein kinase regulates activation and nuclear localization of Snf1-Gal83 protein kinase.
Molecular and cellular biology - 1 Sept 2004
Hedbacker Kristina, Hong Seung-Pyo, Carlson Marian
Abstract excerpt
Three kinases, Pak1, Tos3, and Elm1, activate Snf1 protein kinase in Saccharomyces cerevisiae. This cascade is conserved in mammals, where LKB1 activates AMP-activated protein kinase. We address the specificity of the activating kinases for the three forms of Snf1 protein kinase containing the beta-subunit isoforms Gal83, Sip1, and Sip2. Pak1 is the most important kinase for activating Snf1-Gal83 in response to...
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