Article
Biochemical and functional studies on the regulation of the Saccharomyces cerevisiae AMPK homolog SNF1.
Biochemical and biophysical research communications - 25 Jun 2010
Amodeo Gabriele A, Momcilovic Milica, Carlson Marian, Tong Liang
Abstract excerpt
AMP-activated protein kinase (AMPK) is a master metabolic regulator for controlling cellular energy homeostasis. Its homolog in yeast, SNF1, is activated in response to glucose depletion and other stresses. The catalytic (alpha) subunit of AMPK/SNF1, Snf1 in yeast, contains a protein Ser/Thr kinase domain (KD), an auto-inhibitory domain (AID), and a region that mediates interactions with the two regulatory (beta...
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