Article
Protein kinase A contributes to the negative control of Snf1 protein kinase in Saccharomyces cerevisiae.
Eukaryotic cell - 1 Feb 2012
Barrett LaKisha, Orlova Marianna, Maziarz Marcin, Kuchin Sergei
Abstract excerpt
Snf1 protein kinase regulates responses to glucose limitation and other stresses. Snf1 activation requires phosphorylation of its T-loop threonine by partially redundant upstream kinases (Sak1, Tos3, and Elm1). Under favorable conditions, Snf1 is turned off by Reg1-Glc7 protein phosphatase. The reg1 mutation causes increased Snf1 activation and slow growth. To identify new components of the Snf1 pathway, we...
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