Article
Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases.
Proceedings of the National Academy of Sciences of the United States of America - 22 Jul 2003
Hong Seung-Pyo, Leiper Fiona C, Woods Angela, Carling David, Carlson Marian
Abstract excerpt
The Snf1/AMP-activated protein kinase (AMPK) family plays fundamental roles in cellular responses to metabolic stress in eukaryotes. In humans, AMPK regulates lipid and glucose metabolism and has been implicated in such metabolic disorders as diabetes and obesity and in cardiac abnormalities. Snf1 and AMPK are the downstream components of kinase cascades, but the upstream kinase(s) have remained elusive. We have...
Topics
- AMP-Activated Protein Kinase Kinases
- Binding Sites
- Enzyme Activation
- Humans
- In Vitro Techniques
- Mutation
- Peutz-Jeghers Syndrome
- Phenotype
- Phosphorylation
- Protein Kinases
- Protein Serine-Threonine Kinases
- Recombinant Fusion Proteins
- Saccharomyces cerevisiae