Article
Snf1/AMPK promotes S-phase entrance by controlling CLB5 transcription in budding yeast.
Cell cycle (Georgetown, Tex.) - 1 Jun 2010
Pessina Stefania, Tsiarentsyeva Viktoryia, Busnelli Sara, Vanoni Marco, Alberghina Lilia, Coccetti Paola
Abstract excerpt
The Saccharomyces cerevisiae Snf1 protein kinase has been reported to be required for adaptation to glucose limitation and for growth on non-fermentable carbon sources. Here we present novel findings indicating that Snf1, the key regulator of cellular energy, is also involved in yeast cell cycle control. The lack of Snf1 α-catalytic subunit down-regulates the growth rate and CLB5 expression, delaying Sld2...
Topics
- Cell Cycle Proteins
- Cyclin B
- Down-Regulation
- G1 Phase
- Glucose
- Mutation
- Phosphorylation
- Protein Serine-Threonine Kinases
- Protein Subunits
- S Phase
- Saccharomyces cerevisiae