Article
MHC2TA is associated with differential MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction.
Nature genetics - 1 May 2005
Swanberg Maria, Lidman Olle, Padyukov Leonid, Eriksson Per, Akesson Eva, Jagodic Maja, Lobell Anna, Khademi Mohsen, Börjesson Ola, Lindgren Cecilia M, Lundman Pia, Brookes Anthony J, Kere Juha, Luthman Holger, Alfredsson Lars, Hillert Jan, Klareskog Lars, Hamsten Anders, Piehl Fredrik, Olsson Tomas
Abstract excerpt
Antigen presentation to T cells by MHC molecules is essential for adaptive immune responses. To determine the exact position of a gene affecting expression of MHC molecules, we finely mapped a previously defined rat quantitative trait locus regulating MHC class II on microglia in an advanced intercross line. We identified a small interval including the gene MHC class II transactivator (Mhc2ta) and, using a map...
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