Article
Natural polymorphisms in Tap2 influence negative selection and CD4∶CD8 lineage commitment in the rat.
PLoS genetics - 1 Feb 2014
Tuncel Jonatan, Haag Sabrina, Yau Anthony C Y, Norin Ulrika, Baud Amelie, Lönnblom Erik, Maratou Klio, Ytterberg A Jimmy, Ekman Diana, Thordardottir Soley, Johannesson Martina, Gillett Alan, Stridh Pernilla, Jagodic Maja, Olsson Tomas, Fernández-Teruel Alberto, Zubarev Roman A, Mott Richard, Aitman Timothy J, Flint Jonathan, Holmdahl Rikard
Abstract excerpt
Genetic variation in the major histocompatibility complex (MHC) affects CD4∶CD8 lineage commitment and MHC expression. However, the contribution of specific genes in this gene-dense region has not yet been resolved. Nor has it been established whether the same genes regulate MHC expression and T cell selection. Here, we assessed the impact of natural genetic variation on MHC expression and CD4∶CD8 lineage...
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