Article
Role of the MHC2TA gene in autoimmune diseases.
Annals of the rheumatic diseases - 1 Mar 2007
Martínez Alfonso, Sánchez-Lopez Marta, Varadé Jezabel, Mas Ana, Martín M Carmen, de Las Heras Virginia, Arroyo Rafael, Mendoza Juan Luis, Díaz-Rubio Manuel, Fernández-Gutiérrez Benjamín, de la Concha Emilio G, Urcelay Elena
Abstract excerpt
OBJECTIVES: Expression of major histocompatibility complex (MHC) class II genes is almost exclusively regulated by the class II transactivator. A promoter polymorphism (-168A/G, rs3087456) in the MHC2TA gene was associated with increased susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction in a northern European population. However, no evidence of association of this MHC2TA variant...
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