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Article

Effects of C2ta genetic polymorphisms on MHC class II expression and autoimmune diseases.

Immunology - 1 Apr 2017

Yau Anthony C Y, Piehl Fredrik, Olsson Tomas, Holmdahl Rikard

Abstract excerpt

Antigen presentation by the MHC-II to CD4+ T cells is important in adaptive immune responses. The class II transactivator (CIITA in human and C2TA in mouse) is the master regulator of MHC-II gene expression. It coordinates the transcription factors necessary for the transcription of MHC-II molecules. In humans, genetic variations in CIITA have been associated with differential expression of MHC-II and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Histocompatibility Antigens Class II

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Source

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Identifiers

PMID: 27861821
DOI: 10.1111/imm.12692
PMCID: PMC5343355

Genes

CIITA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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