Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Allelic difference in Mhc2ta confers altered microglial activation and susceptibility to α-synuclein-induced dopaminergic neurodegeneration.

Neurobiology of disease - 1 Oct 2017

Jimenez-Ferrer Itzia, Jewett Michael, Tontanahal Ashmita, Romero-Ramos Marina, Swanberg Maria

Abstract excerpt

Parkinson's Disease (PD) is a complex and heterogeneous neurodegenerative disease characterized by a progressive loss of dopaminergic neurons in the substantia nigra pars compacta and pathological intracellular accumulation of alpha-synuclein (α-syn). In the vast majority of PD patients, the disease has a complex etiology, defined by multiple genetic and environmental risk factors. Common genetic variants in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Synuclein
Share to Corpus Striatum

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dependovirus

Share to Dopaminergic Neurons

Share to Microglia

Share to Nerve Degeneration

Share to Parkinsonian Disorders

Share to Rats, Transgenic

Source

Identifiers

PMID: 28736195
DOI: 10.1016/j.nbd.2017.07.016

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Allelic difference in Mhc2ta confers altered microglial activation and susceptibility to α-synuclein-induced dopaminergic neurodegeneration.PMID 28736195Read ↗

MHC class II transactivator effects on local and systemic immune responses in an α-synuclein seeded rat model for Parkinson’s diseaseSemantic proximity Read ↗

The MHC class II transactivator affects local and systemic immune responses in an α-synuclein seeded rat model for Parkinson’s diseaseSemantic proximity Read ↗

MHCII reduction is insufficient to protect mice from alpha-synuclein-induced degeneration and the Parkinson’s HLA locus exhibits epigenetic regulationSemantic proximity Read ↗

Targeting of the class II transactivator attenuates inflammation and neurodegeneration in an alpha-synuclein model of Parkinson’s diseaseSemantic proximity Read ↗

Shared Epitope-Positive HLA Alleles Protect Against Alpha-Synuclein Pathology in a Model of Parkinson Disease.Semantic proximity Read ↗

Angiotensin Type 1 Receptor Antagonists Protect Against Alpha-Synuclein-Induced Neuroinflammation and Dopaminergic Neuron Death.Semantic proximity Read ↗

MHC2TA is associated with differential MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction.Semantic proximity Read ↗

Microbiota-dependent T-cell response to α-synuclein-derived antigens triggers the development of hypersensitivity and neuroinflammation associated with Parkinson's DiseaseSemantic proximity Read ↗

Immunogenetic Factors of Neurodegenerative Diseases: The Role of HLA Class IISemantic proximity Read ↗

Lack of neuroprotection after systemic administration of the soluble TNF inhibitor XPro1595 in an rAAV6-α-Syn+PFFs-induced rat model for Parkinson’s diseaseSemantic proximity Read ↗

Differential nerve injury-induced expression of MHC class II in the mouse correlates to genetic variability in the type I promoter of C2ta.Semantic proximity Read ↗

<i>LRRK2</i> G2019S mutation suppresses differentiation of Th9 and Treg cells via JAK/STAT3Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.