Article
Single nucleotide polymorphisms in MHC2TA, the gene encoding the MHC class II transactivator (CIITA).
Genes and immunity - 1 Feb 2002
Patarroyo J C, Stuve O, Piskurich J F, Hauser S L, Oksenberg J R, Zamvil S S
Abstract excerpt
The MHC class II transactivator (CIITA) is the master regulator for HLA-D (DP, DQ, DR) gene expression. In this report the coding and promoter regions of the CIITA gene, MHC2TA, were evaluated for polymorphisms in 50 normal Caucasian individuals. Allele frequencies were obtained for four separate single nucleotide (nt) polymorphisms (SNPs) identified in the MHC2TA coding region: nt 1614 (C-->G), nt 2509 (G-->A),...
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