Article
The calpain system is involved in the constitutive regulation of beta-catenin signaling functions.
The Journal of biological chemistry - 10 Jun 2005
Benetti Roberta, Copetti Tamara, Dell'Orso Stefania, Melloni Edon, Brancolini Claudio, Monte Martin, Schneider Claudio
Abstract excerpt
Beta-catenin is a multifunctional protein serving both as a structural element in cell adhesion and as a signaling component in the Wnt pathway, regulating embryogenesis and tumorigenesis. The signaling fraction of beta-catenin is tightly controlled by the adenomatous polyposis coli-axin-glycogen synthase kinase 3beta complex, which targets it for proteasomal degradation. It has been recently shown that Ca(2+)...
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