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Article

APC is essential for targeting phosphorylated beta-catenin to the SCFbeta-TrCP ubiquitin ligase.

Molecular cell - 5 Dec 2008

Su YunYun, Fu Chunjiang, Ishikawa Shinji, Stella Alessandra, Kojima Masayuki, Shitoh Kazuhisa, Schreiber Emanuel M, Day Billy W, Liu Bo

Abstract excerpt

Ubiquitin-dependent proteolysis is an important mechanism that suppresses the beta-catenin transcription factor in cells without Wnt stimulation. A critical step in this regulatory pathway is to create a SCF(beta-TrCP) E3 ubiquitin ligase binding site for beta-catenin. Here we show that the SCF(beta-TrCP) binding site created by phosphorylation of beta-catenin is highly vulnerable to protein phosphatase 2A (PP2A)...

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Source

Identifiers

PMID: 19061640
DOI: 10.1016/j.molcel.2008.10.023

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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