The Calpain System as a Modulator of Stress/Damage Response

Abstract excerpt

Ubiquitously expressed mu- and m-calpain proteases consist of 80-kDa catalytic subunits encoded by the Capn1 and Capn2 genes, respectively, and a common 28-kDa regulatory subunit encoded by the calpain small 1 (Capns1) gene. The mu- and m-calpain proteases have been implicated in both pro-or anti-apoptotic functions. We have found that Capns1 depletion is coupled to increased sensitivity to increased sensitivity...

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