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Article

Beta-catenin cleavage enhances transcriptional activation.

Scientific reports - 12 Jan 2018

Goretsky Tatiana, Bradford Emily M, Ye Qing, Lamping Olivia F, Vanagunas Tomas, Moyer Mary Pat, Keller Patrick C, Sinh Preetika, Llovet Josep M, Gao Tianyan, She Qing-Bai, Li Linheng, Barrett Terrence A

Abstract excerpt

Nuclear activation of Wnt/β-catenin signaling is required for cell proliferation in inflammation and cancer. Studies from our group indicate that β-catenin activation in colitis and colorectal cancer (CRC) correlates with increased nuclear levels of β-catenin phosphorylated at serine 552 (pβ-Cat552). Biochemical analysis of nuclear extracts from cancer biopsies revealed the existence of low molecular weight (LMW)...

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PMID: 29330435
DOI: 10.1038/s41598-017-18421-8
PMCID: PMC5766502

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TCF4

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