Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex.

Cell - 8 Jun 2012

Li Vivian S W, Ng Ser Sue, Boersema Paul J, Low Teck Y, Karthaus Wouter R, Gerlach Jan P, Mohammed Shabaz, Heck Albert J R, Maurice Madelon M, Mahmoudi Tokameh, Clevers Hans

Abstract excerpt

Degradation of cytosolic β-catenin by the APC/Axin1 destruction complex represents the key regulated step of the Wnt pathway. It is incompletely understood how the Axin1 complex exerts its Wnt-regulated function. Here, we examine the mechanism of Wnt signaling under endogenous levels of the Axin1 complex. Our results demonstrate that β-catenin is not only phosphorylated inside the Axin1 complex, but also...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenomatous Polyposis Coli Protein
Share to Axin Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to beta Catenin

Share to Colonic Neoplasms

Share to Glycogen Synthase Kinase 3

Share to Glycogen Synthase Kinase 3 beta

Share to Proteasome Endopeptidase Complex

Share to Wnt Signaling Pathway

Source

Identifiers

PMID: 22682247
DOI: 10.1016/j.cell.2012.05.002

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex.PMID 22682247Read ↗

Wnt/Wingless Pathway Activation Is Promoted by a Critical Threshold of Axin Maintained by the Tumor Suppressor APC and the ADP-Ribose Polymerase Tankyrase.Semantic proximity Read ↗

The effect of Wnt signaling on the localization, molecular size and activity of the beta-catenin destruction complex in vivoSemantic proximity Read ↗

APC controls Wnt-induced β-catenin destruction complex recruitment in human colonocytes.Semantic proximity Read ↗

Unexpectedly robust assembly of the Axin destruction complex regulates Wnt/Wg signaling in Drosophila as revealed by analysis in vivo.Semantic proximity Read ↗

The links between axin and carcinogenesisSemantic proximity Read ↗

Hepatocellular carcinoma-associated <i>AXIN1</i> mutations drive low levels of Wnt/β-catenin pathway activity that allow for niche-independent growth and YAP/TAZ signalingSemantic proximity Read ↗

Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3βSemantic proximity Read ↗

Mutational scanning reveals substrate-assisted autoregulation of the WNT destruction complexSemantic proximity Read ↗

Analysis of Tumor-Associated AXIN1 Missense Mutations Identifies Variants That Activate β-Catenin SignalingSemantic proximity Read ↗

Mutational scanning reveals substrate-assisted autoregulation of the WNT destruction complex.Semantic proximity Read ↗

Reversible modification of adenomatous polyposis coli (APC) with K63-linked polyubiquitin regulates the assembly and activity of the β-catenin destruction complex.Semantic proximity Read ↗

Activation of AXIN2 expression by beta-catenin-T cell factor. A feedback repressor pathway regulating Wnt signaling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.